Why Mice Don’t Get Ulcers


In his 1994 book “Why Zebras Don’t Get Ulcers,” Robert Sapolsky described the difference between the types of stress that people often experience and the ones that other animal species do. In his titular example, if you were a zebra, you’d most likely face acute physical stress – the lion about to eat you – which requires immediate physiological adaptations (the fight-or-flight response). A second type of stress might be chronic and physical (drought, famine, parasites, etc.).

However, the third type of stress on Sapolsky’s list – the type most prominent in an industrialized human’s life – was social and psychological. While our species certainly benefited from expanding brain size over the last few million years, it too came with trade-offs, including the ability to overthink and worry about things to come down the road. This type of stress would not have featured too prominently into the mental lives of other species. As Sapolsky wrote:

“How many hippos worry about whether Social Security is going to last as long as they will, or what they are going to say on a first date? 

For the vast majority of beasts on this planet, stress is about a short-term crisis, after which it’s either over with or you’re over with. When we sit around and worry about stressful things, we turn on the same physiological responses – but they are potentially a disaster when provoked chronically. A large body of evidence suggests that stress-related disease emerges, predominantly, out of the fact that we so often activate a physiological system that has evolved for responding to acute physical emergencies, but we turn it on for months on end, worrying about mortgages, relationships and promotions” (p. 5 – 6).

The idea is that human evolved physiology has tinkered with a stress response system and modified it to fit our complex, intensely social lives. In some circumstances, the response shifts into overdrive and backfires, leading to chronic illness.

I was reminded about these things while reading Robert Burns’ 1785 poem “To A Mouse.” I re-checked Sapolsky’s book and can’t find a mention of “To A Mouse,” but I think it would have fit perfectly there. In the poem, Burns sympathizes with a mouse whose home (“a wee bit heap of leaves and stibble”) he accidentally destroyed while tilling his field, just before the coming winter. The best-known line of the poem is surely “The best-laid schemes o’ mice an’ men.” However, the stanza that follows epitomizes Sapolsky’s distinction between humans worrying about an array of stressors including past and future events, while other species remain focused on more immediate circumstances. The key part:

[Burns’ original]                                   

Still thou art blest, compar’d wi’ me  

The present only toucheth thee:            

But, Och! I backward cast my e’e.         

On prospects drear!                                 

An’ forward, tho’ I canna see,                

I guess an’ fear!                                         

[If the above is slightly confusing, Burns was writing in Scots. This makes sense, given that he is the national poet of Scotland. You can find a English translation of “To A Mouse” here.]

Of course, this isn’t to say that mice never get ulcers. They do. But the larger point still stands — that our large brains, capable of foresight and worry, come with a cost.

Finally, here is a wonderful reading of “To A Mouse.” The accent alone makes it worth listening…

2 thoughts on “Why Mice Don’t Get Ulcers

  1. I started to read your blog with the last entry about truth before just reading this post about worries and ulcers and the difference between animals and humans on this issue. How much truth is in it?
    Does worrying really provoke ulcer? I thought that the last medical point of view about it was that ulcers were induced by bacterial infect’s and could be cured by antibiotics.
    Do zebras never worry about social issues ? How can we know for sure that they don’t worry ? Zebras live in herds with social components and behaviours. Living in herds is very important for their survival. Being ostracised from the herd could induce a lot of fear. How do we know that they don’t worry about being ostracised ?

    • Hi, you are right that a species of bacteria (H. pylori) is a major risk factor for ulcers. However, I don’t think that’s the only one. Stress or worry does seem to be another.

      You’re also right that other species probably have a sense of anxiety about social problems (at least those species that are social). If we share so much physically with them, then it makes sense that we probably share similar emotional states as well. However, I think that similarity is a matter of degree and not kind. We probably take this to the extreme, since we are one of the most intensely social species on earth.

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