According to one estimate, about 108 billion humans have ever lived. The exact number is probably unknowable. However, one thing we can know with certainty is that all of them have been fallible. So far they have also all been mortal. And with billions of years of life behind us, we have enough data to indicate that pattern is likely to continue, unless there is an exception alive out there today (I doubt it).
In any case, the fallible humans have a number of consistent flaws and frailties in our biology — senescence, bad backs, myopia, etc. We should expect evolved beings to have built-in limitations in their biology. My favorite quote explaining why this should be comes from Matt Cartmill, who once said: “Evolution doesn’t act to yield perfection. It acts to yield function.”