“Development is the missing link between genotype and phenotype, a place too often occupied by metaphors in the past … But a strong emphasis on the genome means that environmental influence is systematically ignored. If you begin with DNA and view development as “hard-wired,” you overlook the flexible phenotype and the causes of its variation that are the mainsprings of adaptive evolution.” (Mary Jane West-Eberhard, 2003: 89-90)
“Genes, unlike gods, are conditional. They are exquisitely good at simple if-then logic: if in a certain environment, then develop in a certain way… So here is the first moral of the tale: Don’t be frightened of genes. They are not gods; they are cogs. (Matt Ridley, 2003: 250)
Plasticity: actor Christian Bale at two points in time. Same genes, different phenotypes.
In his book The Triple Helix, Richard Lewontin told the story of the molecular biologist and Nobel laureate Sydney Brenner, who – while speaking at a conference – predicted that one day we would be able to “compute” an organism (2002). All we would need are two things: the organism’s full genome and powerful enough computers that were up to the task.
The idea is seductive. Genes are sometimes seen as self-sufficient molecules, almost existing in a vacuum, that contain all the information necessary to code for proteins. From there, it’s not a very big logical leap to think that if you had the genome, you could enter the code in some database, hit “run,” and then watch some digitized version of the organism unfold.
In fact, scientists are doing something much like this for the tiny roundworm C. elegans with the project OpenWorm. Yet even for a relatively simple organism such as this, with only about a thousand cells in total, there are reasons to be cautious. As The Economist warned in its write-up of OpenWorm: “Attempting to simulate everything faithfully would bring even a supercomputer to its knees.” However, this isn’t due solely to the limits of computing power (what if we had a super-duper computer!?). Rather, it’s a matter of how the question is framed.
Continue reading →